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  Numerous research initiatives have investigated how NAD precursors counteract the age-related loss in this key coenzyme involved in cellular energy metabolism and energy generation, with an emphasis on exercise metabolism and body composition. However, it has not been studied if NMN supplementation helps metabolism, much alone aging, in humans. Klein and colleagues from the Washington University School of Medicine in St. Louis published a study in Science demonstrating for the first time that NMN metabolism enhances the insulin sensitivity of pre-diabetic women's skeletal muscles. They demonstrate that NMN achieves these beneficial metabolic benefits by improving the capacity of insulin to induce sugar absorption and the activation of genes involved in muscle structure and remodeling. However, the Missouri-based study team could not uncover evidence that NMN affects fat blood levels, blood sugar levels, or blood pressure. This article from Science gives tantalizing evidence that...