Breakthroughs In Human Clinical Trials With NMN

The classification of ageing as a disease opens the way for new research into reverse age-related illnesses such as cardiovascular, cancer, and metabolic disease, and neurodegeneration like Alzheimer’s and Parkinson’s diseases.

 

Nutrient sensing systems have been an intense focus of research, including the mammalian target of rapamycin for regulating protein synthesis and cell growth, a family of seven proteins critical to DNA expression and ageing, which can only function with NAD+ (nicotinamide adenine dinucleotide), an essential enzyme present in all living cells. 

 

 NMN Clinical trial have proved that boosting NAD+ levels increases mitochondrial dysfunction, and insulin sensitivity, and reverses and extends the lifespan of human beings.

 

Pathways To NMN In The Human Body

 

The body cells allow NAD+ to be both regulated and synthesised in our body. Vitamin B3 is a base for Nicotinamide adenine dinucleotide (NAD+).

 

phosphoribosyltransferase (NAMPT), a coenzyme that converts from nicotinamide to NMN, which exists in both an extracellular form (eNAMPT) and intracellular (iNAMPT). The extracellular has higher enzymatic activity when compared to the intercellular form which is found in seminal plasma, blood plasma and cerebrospinal fluid in humans.

 

NMN is converted to NR by the body,  then enters cells, and is converted back to NMN by an essential enzyme called nicotinamide riboside kinase (NRK). NMN is transported across the cell membranes into the cytoplasm of the living cell, by an essential enzyme called Slc12a8. 

 

NMN levels fall with ageing and it has also resulted in significantly compromising the body’s conversion of NMN to NAD+.

 

A clinical trial with NMN

Shin-ichiro Imai, MD, PhD, professor of developmental biology is a leader in NMN research. The focus of his research is ageing and longevity. He researches mice to check the possibility of slow signs of ageing, boost energy, and rejuvenate metabolism in humans. But when it comes to supplements on the market, there are two sources of NMN which have been extensively tested in both rodents and humans.

 

Imai was the first one to contact research to prove that NMN works in mice. His lab demonstrated that giving NMN to mice over 12 months shows remarkable anti-ageing effects. The results to humans show that  NMN could provide a person with a metabolism 10 to 20 years younger than before.

 

The NAD molecule is the most important element in our cells. Past studies have shown NAD levels in tissues in our body decrease with age. Research said that NMN can boost NAD production and  “slow down” ageing.

 

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