How much NMN should I take?

 

What is NMN (nicotinamide mononucleotide)?

A naturally occurring chemical called NMN gives your body energy.


A nucleotide is a class of chemicals that includes NMN. The building blocks of DNA are only one of the many roles of nucleotides in the human body.


NMN is transformed by your cells into a different chemical called nicotinamide adenine dinucleotide (NAD). Your body requires NAD for a number of metabolic and energy-producing processes.


Consider NAD as the polished form your body can utilise and NMN as the raw material.


The amount of NMN in your body determines how much NAD your body can produce.


Benefits


All the cells in your body use NAD, so they all need NMN, a precursor to NAD. NAD helps cells control many essential tasks that keep your cells working well, such as:


  • energy metabolism

  • DNA repair

  • gene expression

  • cellular stress responses


For your cells to make enough NAD to support these functions, they need a lot of NMN.

Your NMN levels go down on their own over time, so your NAD levels go down. This could cause some health problems you might have as you age.

For example, research has shown that people with diabetes and liver diseases may have lower levels of NMN and NAD.


Tests in test tubes and on animals also say that NMN may be necessary for the health of the heart and brain and other parts of ageing.

How Much NMN should I take?

Most studies on rodents show that NMN prevents age-related diseases using doses of about 300 mg/kg. So, a person who weighs 75 kg (about 165 pounds) would need 22,500 mg (22.5 g). Given how much NMN costs, this would cost more than $100 per dose and, if taken every day, more than $35,000 per year if taken once a day.


However, bigger species like humans do not require such potent amounts. According to a scientific theory known as "volume of distribution," rodents like mice need 12.3 times the part of chemicals humans do. As a result, a 75 kg person would require around 1.829 grammes for the same impact as a 300 mg/kg dose in mice, equivalent to 24.39 mg/kg in humans. Remember that the 300 mg/kg dose in mice is regarded as a "heavy" dose and likely supplies more NMN than is required for effectiveness. The question then becomes, "How much NMN must an individual consume for it to be effective?"

According to a study on mice, 100 mg/kg daily reduced most age-related physiological decline. Based on this dosage, For a typical adult weighing 62 kg (about 137 pounds), the suggested daily dose is roughly 500 mg. This figure is based on dividing the human dosage by 12.3 to match the "volume of distribution" in rodents. Similarly, larger adults weighing 90 kg should take approximately 750 mg daily.



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