What is the optimal dosage of NMN to achieve the desired effect?

 

Nicotinamide mononucleotide (NMN) is a potent anti-aging, weight reduction, energy enhancement, cardiovascular health, vision, and diabetes agent. Additionally, it operates by combating cell damage and other forms of oxidative stress. Although NMN provides several health advantages, its dose forms are not governed by formal guidelines. Nonetheless, research on rats has deemed it safe for human usage, and human clinical studies are now underway.

Studies on the NMN effective dosage

As with determining the optimal NMN dose per day, there needs to be more research regarding the optimal time to take the supplement. Age may also play a role in deciding when to administer NMN.

Using a model replicating the circadian clock and metabolism in the mouse liver, researchers from the University of Waterloo in Canada determined that younger persons should ingest NMN six hours after waking up for maximum efficiency.

A Japanese research team tested the safety of oral dosages of NMN up to 500 mg in humans and observed no changes in physiological parameters such as heart rate and blood pressure. This study provides evidence that a single NMN dosage of up to 500 mg is safe and well-tolerated.

Scientists from the Washington University School of Medicine in St. Louis discovered that oral administration of 250 mg of NMN daily for ten weeks enhances the muscle insulin sensitivity and structure of older women. These data indicate that cheaper NMN dosages of 250 mg daily can be safe and effective for improving insulin sensitivity in skeletal muscle.

In another study, researchers from the University of Tokyo found that giving guys over 65 an oral dose of 250 milligrams of NMN per day for twelve weeks improved their muscle performance. Supplementation with NMN improved walking speed, the ability to rise from a chair without assistance, and grip strength in senior males.

In addition, ongoing clinical trials evaluate the safety of long-term administration of 200 to 300 mg/day of NMN for up to 24 weeks. The effectiveness of NMN in enhancing cardiometabolic function, glucose metabolism, and other health indicators is also being evaluated in middle-aged and elderly individuals with age-related illnesses such as hypertension, diabetes, obesity, and malnutrition.

David Sinclair, a professor at Harvard who researches aging, has recommended NMN to maintain health and prevent aging. According to Dr. Sinclair, he takes 1 gram of NMN daily, in addition to resveratrol, metformin, and aspirin, with no adverse side effects.

One of the most recent research demonstrates that ingesting 2000 mg of NMN has no adverse side effects and is beneficial. Another Japanese study concluded that 125 mg of NMN twice daily for eight weeks benefits health. There are currently no data on the long-term use of NMN.

After taking into account the findings of both human and animal research on the effectiveness and safety of NMN and determining the ideal dosages, the daily dosage of 500 milligrams that is suggested for individuals aged 30 to 60 years old is as follows: To get the most out of the advantages of NMN, those over the age of 65 can safely use 750 mg per day.

Note - 

The recommended dose of NMN (Nicotinamide Mononucleotide) varies depending on various factors such as age, weight, and overall health. However, the typical recommended daily dose of NMN is 250-500mg per day.